Fig. 5
From: DNA-PKcs participated in hypoxic pulmonary hypertension
DNA-PKcs specific inhibitor (NU7026) prevented pulmonary hypertension in hypoxic rats. A Treatment for rat models of hypoxic PH. B NU7026 prevented pulmonary vascular remodeling in hypoxic rats. C, D NU7026 prevented right ventricular systolic pressure (RVSP) and right ventricular hypertrophy index [RV/(LV + S)]. E, F Changes of body weight and mean systemic blood pressure. G NU7026 suppressed protein levels of DNA-PKcs, NOR1 and cyclin D1 in hypoxic PH. H No pathological change was observed in liver and kidney after NU7026 treatment. Bar 100 µm