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Fig. 2 | Respiratory Research

Fig. 2

From: DNA-PKcs participated in hypoxic pulmonary hypertension

Fig. 2

DNA-PKcs specific siRNA suppressed hypoxia-induced PASMCs proliferation. A Edu assays and CCK-8 assays for hypoxia-induced proliferation. B CCK-8 assay for hypoxic proliferation. C, D Immunohistochemistry staining and western-blot for expression of PCNA and DNA-PKcs after hypoxia exposure. E Elevated DNA-PKcs levels in endothelin cells after hypoxia exposure. F, G specific siRNA inhibited elevated levels of DNA-PKcs mRNA and protein in hypoxic PASMCs. H–K Specific siRNA suppressed hypoxia-induced proliferation (CCK-8 assay, Edu assay and immunohistochemistry staining). *P < 0.05, ***P < 0.05, as compared with nomoxia or si-NC. PCNA: proliferating cell nuclear antigen, NC: negative control. Bar 100 µm

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