Fig. 1

DNA-PKcs up-regulated in lung tissues from HPH rats and COPD patients with hypoxemia. A Expression of DNA-PKcs in PAH from GEO database. B Establishment of rats HPH models. C, D Pulmonary vascular remodeling and DNA-PKcs elevation in rat HPH models. E Western-blot detection for DNA-PKcs protein levels in explants of rat small pulmonary arteries. F, G Pulmonary vascular remodeling in lungs from COPD patients with hypoxemia. H–K DNA-PKcs, NOR1 and cyclin D1 levels in COPD patients with hypoxaemia. Bar 200 µm