Fig. 7

Intranasal administration of si-IL-24 or IL-37 inhibited the activation of the p-STAT3 and p-ERK1/2 signaling pathways in the lungs of an HDM-induced asthma murine model. a–d Representative immunofluorescence images of p-STAT3 and p-ERK1/2 expression in mouse lung tissues. Scale bar = 100 μm (× 630). e–h Representative immunoblot analysis and quantification of p-STAT3 and p-ERK1/2 expression in lung tissues of mice (n = 8/group). Bar diagrams and data are presented as the mean ± standard deviation (SD) from three replicate experiments. * vs. PBS group; ^& vs. HDM group. *^,&P < 0.05; **^,&&P < 0.01; ***^,&&&P < 0.001, ****^,&&&&P < 0.0001. si-NC siRNA targeting of negative control