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Fig. 1 | Respiratory Research

Fig. 1

From: IL-37 protects against airway remodeling by reversing bronchial epithelial–mesenchymal transition via IL-24 signaling pathway in chronic asthma

Fig. 1

IL-24 promoted cell migration and EMT in BEAS-2B cells. a The effect of IL-24 (100 ng/ml) on the migration of BEAS-2B cells was evaluated by Transwell assay. Scale bar = 50 μm (× 100). b Quantification of the Transwell assay revealed the number of migrated cells. c Representative images of cell morphology following 100 ng/ml IL-24 stimulation for 48 h. Scale bar = 100 μm (× 200). d Representative immunoblot analysis of E-cadherin, vimentin and α-SMA expression in BEAS-2B cells treated with various concentrations of IL-24 (0–200 ng/ml) for 48 h. e Representative immunoblot analysis of E-cadherin, vimentin, and α-SMA expression in BEAS-2B cells treated with 100 ng/ml IL-24 at different time points. Representative immunofluorescence of E-cadherin (f), vimentin (g) and α-SMA (h) expression in BEAS-2B cells exposed to 100 ng/ml IL-24 for 48 h. Scale bar = 100 μm (× 200). Bar diagrams and data are presented as the mean ± standard deviation (SD) from three replicate experiments. *vs. control group; **P < 0.01

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