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Fig. 3 | Respiratory Research

Fig. 3

From: Cigarette smoke exposed airway epithelial cell-derived EVs promote pro-inflammatory macrophage activation in alpha-1 antitrypsin deficiency

Fig. 3

Induction of ER stress and NF-κB inflammatory pathway in AATD macrophages in response to cigarette smoke. A Comparison of the mRNA expression levels of XBP-1, CHOP, ATF 4, and BiP in normal and AATD macrophages exposed to air or cigarette. B Western blot analysis of 4 different normal and AATD macrophages incubated with control or CS exposed showing activation of NF-κB pathway in AATD macrophages after CS exposure. C Bar graphs showing the results of quantification and normalization of band intensities, *p < 0.05, **p < 0.005, ****p < 0.00005

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