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Table 3 Top pathways associated with the DEGs upon cigarette smoke exposure

From: Early transcriptional responses of bronchial epithelial cells to whole cigarette smoke mirror those of in-vivo exposed human bronchial mucosa

Pathway description Term ID Database source Adj. p-value
1 h upregulated
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 Gene ontology 2.42E−09
Positive regulation of macromolecule metabolic process GO:0010604 Gene ontology 7.73E−08
Positive regulation of nitrogen compound metabolic process GO:0051173 Gene ontology 2.84E−07
Response to hydrogen peroxide GO:0042542 Gene ontology 4.12E−06
Response to organic cyclic compound GO:0014070 Gene ontology 6.88E−06
Positive regulation of apoptotic process GO:0043065 Gene ontology 8.93E−06
4 h upregulated
Response to arsenic-containing substance GO:0046685 Gene ontology 1.96E−07
Positive regulation of cell death GO:0010942 Gene ontology 3.92E−05
Unsaturated fatty acid metabolic process GO:0033559 Gene ontology 5.97E−05
Oxidative Stress WP408 WikiPathways 1.77E−07
NRF2 pathway WP2884 WikiPathways 3.44E−06
Glutamate-cysteine ligase activity GO:0004357 Gene ontology 2.04E−04
24 h upregulated
Nuclear Receptors Meta-Pathway WP2882 WikiPathways 7.85E−06
NRF2 pathway WP2884 WikiPathways 1.86E−05
Aryl Hydrocarbon Receptor Pathway WP2873 WikiPathways 5.17E−05
Ferroptosis KEGG:04216 KEGG 3.31E−05
Iron ion binding GO:0005506 Gene ontology 2.73E−05
Oxidoreductase activity GO:0016491 Gene ontology 1.11E−04
4 h downregulated
Sequence-specific double-stranded DNA binding GO:1990,837 Gene ontology 5.99E−06
Positive regulation of RNA metabolic process GO:0051254 Gene ontology 8.11E−05
Positive regulation of nucleic acid-templated transcription GO:1903508 Gene ontology 1.08E−04
24 h downregulated
F-box domain binding GO:1990444 Gene ontology 3.30E−02
Mitochondrion-derived vesicle GO:0099073 Gene ontology 3.06E−02
  1. No pathway was found related to 1 h downregulated genes