Table 2 Top 15 DEGs at 1 h, 4 h, and 24 h after whole cigarette smoke exposure

1 h

CYP1A1

1.23E−17

1.76E−13

ATF3

2.91E−16

1.39E−12

HMOX1

4.78E−16

1.71E−12

FOSB

8.43E−15

2.01E−11

KLF6

1.52E−14

3.10E−11

TIPARP

1.89E−14

3.38E−11

ZNF331

7.22E−14

1.15E−10

PER1

1.92E−13

2.74E−10

NR4A2

2.73E−13

3.55E−10

CYP1B1

3.27E−13

3.90E−10

SNHG3

7.38E−13

8.12E−10

NR4A1

8.27E−13

8.45E−10

CBARP

1.41E−12

1.34E−09

OVOL1

1.70E−12

1.52E−09

RHOB

2.92E−12

2.46E−09

4 h

TXNRD1

1.38E−32

1.97E−28

UNKL

2.72E−29

1.94E−25

GCLM

1.23E−26

5.87E−23

SQSTM1

1.80E−26

6.45E−23

STX3

4.49E−26

1.28E−22

ZNF469

1.38E−25

3.30E−22

SYNJ2

2.31E−25

4.71E−22

GSR

9.42E−25

1.68E−21

SLC12A7

2.02E−24

3.20E−21

HMOX1

5.57E−24

7.96E−21

GCLC

6.23E−24

8.10E−21

CYP1A1

3.97E−23

4.38E−20

AKR1C3

3.98E−23

4.38E−20

CYP4F3

1.15E−22

1.13E−19

OSGIN1

1.19E−22

1.13E−19

24 h

FTL

9.49E−16

9.61E−12

G6PD

1.34E−15

9.61E−12

TFRC

2.38E−15

1.13E−11

CYP1A1

4.23E−14

1.21E−10

FTH1

9.39E−13

1.92E−09

CYP1B1

1.92E−12

3.04E−09

ALDOC

6.35E−12

7.57E−09

GPR37L1

2.44E−10

1.74E−07

KLF3.AS1

1.22E−09

7.26E−07

KLK6

1.76E−09

9.00E−07

NQO1

2.87E−09

1.37E−06

ALDH3A1

1.29E−08

4.86E−06

SERPINB4

2.60E−08

9.05E−06

PRKN

2.98E−08

1.01E−05

AKR1B10

4.68E−08

1.49E−05