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Table 3 Changes in FEV1/FVC and patterns of ventilatory defect from baseline to 2 weeks, 6 months, and 1 year after surgery

From: Longitudinal changes in pulmonary function and patient-reported outcomes after lung cancer surgery

   

Before surgery

2 weeks after surgery

6 months after surgery

1 year after surgery

Overall

     

 FEV1/FVC (%)

    

  Adjusted mean (SE)

73.9 (0.3)

75.1 (0.3)

74.2 (0.3)

73.6 (0.4)

  Change from baseline (95% CI)a

Reference

1.3 (0.8, 1.7)

0.4 (− 0.1, 0.9)

− 0.3 (− 0.8, 0.3)

 Obstructive pattern

    

  Adjusted proportion (SE)

20.2 (1.5)

20.4 (1.6)

22.1 (1.6)

25.8 (1.8)

  Odds ratio (95% CI)a

Reference

1.0 (0.8, 1.1)

1.0 (0.8, 1.2)

1.2 (1.0, 1.3)

 Restrictive pattern

    

  Adjusted proportion (SE)

7.4 (1.0)

57.8 (1.9)

33.1 (1.9)

23.5 (1.8)

  Odds ratio (95% CI)a

Reference

7.8 (6.0, 10.3)

4.5 (3.4, 5.8)

3.2 (2.4, 4.1)

Type of surgery

    

 FEV1/FVC (%)

    

 Adjusted mean (SE)

    

  Wedge resection/segmentectomy

73.6 (0.7)

74.7 (0.7)

73.4 (0.8)

73.1 (0.8)

  Lobectomy

74.0 (0.3)

75.3 (0.4)

74.3 (0.4)

73.6 (0.4)

  Pneumonectomy/bilobectomy

73.0 (1.7)

74.6 (1.7)

77.4 (1.8)

75.5 (2.0)

  P-values

0.79

0.73

0.12

0.55

 Obstructive pattern

    

 Adjusted proportion (SE)

    

  Wedge resection/segmentectomy

25.1 (3.8)

22.4 (3.7)

24.4 (3.9)

27.2 (4)

  Lobectomy

21.7 (1.7)

21.7 (1.7)

22.3 (1.8)

25.8 (1.9)

  Bilobectomy/pneumonectomy

23.0 (7.3)

17.3 (6.7)

13.5 (6.1)

22.0 (7.7)

  P-values

0.69

0.83

0.44

0.85

 Restrictive pattern

    

 Adjusted proportion (SE)

    

  Wedge resection/segmentectomy

4.9 (2)

44.6 (4.5)

15.5 (3.4)

9.1 (2.8)

  Lobectomy

6.8 (1.1)

60.0 (2.2)

35.8 (2.3)

25.7 (2.1)

  Bilobectomy/pneumonectomy

26.7 (9)

72.3 (10.4)

67.0 (10.9)

48.2 (11.7)

  P-values

 < 0.01

 < 0.01

 < 0.01

 < 0.01

  1. An obstructive pattern was defined as FEV1/FVC < 70%; a restrictive pattern was defined as both FEV1/FVC ≥ 70% and FVC < 80% predicted
  2. CI confidence interval, FEV1 forced expiratory volume in 1 s; FVC forced expiratory vital capacity, SE standard error
  3. aAdjusted for age, sex, stage, obesity, smoking status, cell type, type of surgery, video-assisted thoracic surgery, postoperative pulmonary complications, and adjuvant treatment