Table 2 Changes in pulmonary function from baseline to 2 weeks, 6 months, and 1 year after surgery

Overall

 FVC (mL)

  Adjusted mean (SE)

3600.3 (21.2)

2721.4 (21.5)

3137.7 (23.1)

3268.8 (24.8)

  Change from baseline (95% CI)^a

Reference

− 879 (− 910.3, − 847.6)

− 462.6 (− 495.4, − 429.8)

− 331.6 (− 365.4, − 297.7)

 FVC, % pred

  Adjusted mean (SE)

93.2 (0.5)

70.9 (0.5)

81.6 (0.5)

85.2 (0.6)

  Change from baseline (95% CI)^a

Reference

− 23.3 (− 24.1, − 22.5)

− 12.3 (− 13.2, − 11.4)

− 8.5 (− 9.4, − 7.6)

 FEV₁ (mL)

  Adjusted mean (SE)

2647.0 (16.7)

2033.1 (16.9)

2318.3 (17.9)

2395.2 (18.9)

  Change from baseline (95% CI)^a

Reference

− 613.9 (− 636.2, − 591.6)

− 328.7 (− 352.0, − 305.3)

− 251.7 (− 275.7, − 227.8)

 FEV₁, % pred

  Adjusted mean (SE)

90.4 (0.5)

69.8 (0.5)

79.6 (0.6)

82.6 (0.6)

  Change from baseline (95% CI)^a

Reference

− 20.6 (− 21.3, − 19.9)

− 10.7 (− 11.5, − 10.0)

− 7.8 (− 8.6, − 7.0)

 DLco, ml/min/mmHg

  Adjusted mean (SE)

18.6 (0.1)

15.8 (0.1)

15.9 (0.1)

  Change from baseline (95% CI)^a

Reference

− 4.0 (− 5.1, − 2.9)

− 3.3 (− 4.4, − 2.2)

 DLco, % pred

  Adjusted mean (SE)

90.5 (0.6)

77.5 (0.6)

78.3 (0.6)

  Change from baseline (95% CI)^a

Reference

− 13.0 (− 14.0, − 12.0)

− 12.2 (− 13.2, − 11.2)

Type of surgery

 FVC (mL)

 Adjusted mean (SE)

  Wedge resection/segmentectomy

3648.0 (49.2)

2977.9 (50)

3403.6 (52.8)

3483.3 (56.4)

  Lobectomy

3596.2 (24.2)

2678.7 (24.6)

3102.5 (26.3)

3242.0 (28.1)

  Bilobectomy/pneumonectomy

3394.4 (116.5)

2198.8 (119.8)

2394.8 (125.6)

2624.3 (136.5)

  P-values

0.15

 < 0.01

 < 0.01

 < 0.01

 Change from baseline (95% CI)^a

  Wedge resection/segmentectomy

Reference

− 670.1 (− 739, − 601.2)

− 244.4 (− 315.4, − 173.4)

− 164.7 (− 237.9, − 91.5)

  Lobectomy

Reference

− 917.4 (− 952.1, − 882.7)

− 493.6 (− 530.2, − 457.0)

− 354.2 (− 391.8, − 316.6)

  Bilobectomy/pneumonectomy

Reference

− 1195.6 (− 1358.3, 1032.9)

− 999.6 (− 1165.9, − 833.3)

− 770.1 (− 949.4, − 590.8)

  P for interaction

 < 0.01

 < 0.01

 < 0.01

 FVC, % predicted

 Adjusted mean (SE)

  Wedge resection/segmentectomy

93.4 (1.1)

76.4 (1.1)

87.1 (1.2)

89.3 (1.3)

  Lobectomy

93.3 (0.5)

70.0 (0.5)

81.0 (0.6)

84.7 (0.6)

  Bilobectomy/pneumonectomy

88.9 (2.6)

60.2 (2.7)

65.6 (2.8)

70.8 (3.1)

  P-values

0.25

 < 0.01

 < 0.01

 < 0.01

 Change from baseline (95% CI)^a

  Wedge resection/segmentectomy

Reference

− 17.0 (− 18.6, − 15.4)

− 6.4 (− 8.1, − 4.7)

− 4.1 (− 5.9, − 2.3)

  Lobectomy

Reference

− 23.3 (− 24.1, − 22.5)

− 12.3 (− 13.2, − 11.4)

− 8.5 (− 9.4, − 7.6)

  Bilobectomy/pneumonectomy

Reference

− 28.8 (− 32.6, − 24.9)

− 23.3 (− 27.3, − 19.3)

− 18.2 (− 22.5, − 13.9)

  P for interaction

 < 0.01

 < 0.01

 < 0.01

 FEV₁ (mL)

 Adjusted mean (SE)

  Wedge resection/segmentectomy

2677.9 (38.9)

2206.5 (39.4)

2485.5 (41.1)

2537.4 (43.4)

  Lobectomy

2647.2 (19.1)

2004.8 (19.3)

2295.1 (20.4)

2376.9 (21.6)

  Bilobectomy/pneumonectomy

2449.9 (92.1)

1669.6 (94.3)

1872.2 (97.9)

1981.1 (104.7)

  P-values

0.08

 < 0.01

 < 0.01

 < 0.01

 Change from baseline (95% CI)^a

  Wedge resection/segmentectomy

Reference

− 471.3 (− 520.9, − 421.8)

− 192.4 (− 243.4, − 141.4)

− 140.5 (− 192.8, − 88.2)

  Lobectomy

Reference

− 642.4 (− 667.4, − 617.5)

− 352.1 (− 378.4, − 325.8)

− 270.3 (− 297.2, − 243.5)

  Bilobectomy/pneumonectomy

Reference

− 780.3 (− 897.4, − 663.3)

− 577.7 (− 697.2, − 458.2)

− 468.8 (− 596.9, − 340.7)

  P for interaction

 < 0.01

 < 0.01

 < 0.01

 FEV₁, % pred

 Adjusted mean (SE)

  Wedge resection/segmentectomy

90.3 (1.2)

74.8 (1.2)

84.2 (1.3)

86.3 (1.3)

  Lobectomy

90.6 (0.6)

68.9 (0.6)

79.0 (0.6)

82.2 (0.7)

  Bilobectomy/pneumonectomy

85.2 (2.9)

61.3 (3)

66.8 (3)

70.8 (3.2)

  P-values

0.19

 < 0.01

 < 0.01

 < 0.01

 Change from baseline (95% CI)^a

  Wedge resection/segmentectomy

Reference

− 15.5 (− 17.1, − 13.8)

− 6.0 (− 7.7, − 4.3)

− 4.0 (− 5.8, − 2.1)

  Lobectomy

Reference

− 21.7 (− 22.6, − 20.9)

− 11.6 (− 12.5, − 10.7)

− 8.4 (− 9.4, − 7.5)

  Bilobectomy/pneumonectomy

Reference

− 24.0 (− 27.8, − 20.1)

− 18.4 (− 22.4, − 14.5)

− 14.4 (− 18.9, − 10)

  P for interaction

 < 0.01

 < 0.01

 < 0.01

 DLco, ml/min/mmHg

 Adjusted mean (SE)

  Wedge resection/segmentectomy

18.4 (0.3)

16.9 (0.3)

16.7 (0.3)

  Lobectomy

18.6 (0.1)

15.6 (0.2)

15.7 (0.1)

  Bilobectomy/pneumonectomy

18.4 (0.7)

14.4 (0.8)

15.0 (0.7)

  P-values

0.81

 < 0.01

 < 0.01

 Change from baseline (95% CI)^a

  Wedge resection/segmentectomy

Reference

− 1.5 (− 1.9, − 1.1)

− 1.7 (− 2.2, − 1.3)

  Lobectomy

Reference

− 3.0 (− 3.2, − 2.8)

− 2.9 (− 3.1, − 2.6)

  Bilobectomy/pneumonectomy

Reference

− 4.0 (− 5.1, − 2.9)

− 3.3 (− 4.4, − 2.2)

  P-values

 < 0.01

 < 0.01

 DLco, % pred

 Adjusted mean (SE)

  Wedge resection/segmentectomy

88.4 (1.3)

81.2 (1.3)

81.1 (1.4)

  Lobectomy

91.0 (0.6)

76.6 (0.7)

77.6 (0.7)

  Bilobectomy/pneumonectomy

90.1 (3.1)

71.7 (3.4)

75.4 (3.3)

  P-values

0.21

 < 0.01

0.05

 Change from baseline (95% CI)^a

  Wedge resection/segmentectomy

Reference

− 7.1 (− 0.3, − 5.1)

− 7.3 (− 9.5, − 5.1)

  Lobectomy

Reference

− 14.4 (− 15.5, − 13.3)

− 13.4 (− 14.5, − 12.3)

  Bilobectomy/pneumonectomy

Reference

− 18.5 (− 23.8, − 13.1)

− 14.8 (− 20.2, − 9.4)

  P-values

 < 0.01

 < 0.01