The association between small airway dysfunction and aging: a cross-sectional analysis from the ECOPD cohort

Respiratory Research

Table 4 Multi-adjusted contributions of age to the severity of SAD among CT-defined SAD subjects (n = 549) from total subjects

Outcomes for SAD markers	Unstandardized β	Standardized β	95% CI	P value
CT
LAA₋₉₅₀, %	0.95	0.08	− 0.06,1.95	0.064
LAA₋₈₅₆, %	2.09	0.08	− 0.06, 4.25	0.057
RV, L	− 0.11	− 0.07	− 0.23, 0.02	0.106
TLC, L	− 0.26	− 0.16	− 0.39, − 0.14	< 0.001
IOS
R5, Ka/L/s	0.02	0.10	0.00, 0.04	0.021
R20, Ka/L/s	0.00	0.004	− 0.00, 0.01	0.918
R5–R20, Ka/L/s	0.02	0.13	0.01, 0.03	0.003
X5, Ka/L/s	− 0.02	− 0.14	− 0.04, − 0.01	0.002
AX, Ka/L	0.30	0.16	0.13, 0.47	< 0.001
Fres, Hz	1.75	0.17	0.85, 2.66	< 0.001
Postbronchodilator
MMEF, %predicted	− 3.95	− 0.15	− 6.19, − 1.71	0.001
FEF₅₀, %predicted	− 5.42	− 0.19	− 7.88, − 2.95	< 0.001
FEF₇₅, %predicted	− 0.75	− 0.03	− 2.99, 1.49	0.512

All the models were adjusted for sex, BMI, smoking status, smoking index, educational level, asthma, tuberculosis, chronic bronchitis, annual household income, smokers living at home, parental history of respiratory disease, occupation exposure > 6 months, indoor exposure to biomass for cooking or heating. All the variables of age in these models indicate per 10 years increase
CI confidence interval; β estimate; % percent; definitions of other abbreviations see Table 1

ISSN: 1465-993X