Skip to main content
Fig. 8 | Respiratory Research

Fig. 8

From: Protective effects of calcyclin-binding protein against pulmonary vascular remodeling in flow-associated pulmonary arterial hypertension

Fig. 8

Decrease in CacyBP/SIP expression resulted in increased PCNA and reduced CALP expression. a Representative IHC images showing expression of PCNA and CALP in the pulmonary arterioles in the indicated groups. Scale bars, 20 µm. b Quantification of the expression of PCNA and CALP in lung tissues. AOD, calculated as the integrated option density/area, was used to quantify expression of PCNA and CALP. Data are shown as mean ± SEM (n = 6 for each group). The difference was compared between AAV-GV143 + MCT-AV and AAV-GV143 + sham groups, and between AAV-siCacyBP + MCT-AV and AAV-GV143 + MCT-AV groups. *: AAV-GV143 + MCT-AV vs. AAV-GV143 + sham; #: AAV-siCacyBP + MCT-AV vs. AAV-GV143 + MCT-AV. ***P < 0.001; #P < 0.05. IHC immunohistochemistry, AAVs adeno-associated viruses, CacyBP/SIP calcyclin-binding protein, CALP calponin, MCT monocrotaline, AV aortocaval, PAH pulmonary arterial hypertension, AOD average optical density

Back to article page