Fig. 3

CacyBP/SIP regulated hPASMC proliferation and migration. a After transfection with Adv-siCacyBP, proliferation and migration of hPASMCs were enhanced. Scale bars (white: 25 µm; blue: 500 µm; black: 200 µm; yellow: 500 µm). b Summary of EdU, cell count, wound healing, and transwell assays in the indicated groups. Data are shown as mean ± SEM (n = 3 for each group). Differences were compared between the Adv-siCacyBP and Adv-GV119 groups, and between the Adv-CacyBP and Adv-GV314 groups. *Adv-siCacyBP vs Adv-GV119; #Adv-CacyBP vs Adv-GV314. *P < 0.05, **P < 0.01; ##P < 0.01, ###P < 0.001. EdU 5-ethynyl-2’-deoxyuridine, hPASMC human pulmonary artery smooth muscle cell, CacyBP/SIP calcyclin-binding protein