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Fig. 8 | Respiratory Research

Fig. 8

From: Upregulating carnitine palmitoyltransferase 1 attenuates hyperoxia-induced endothelial cell dysfunction and persistent lung injury

Fig. 8

Treatment with l-carnitine and baicalin ameliorated hyperoxia-induced persistent alveolar and vascular simplification. C57BL/6 J mice (< 12 h old) were exposed to 95% (A–C, F, G) or 50% (D, E, H) O2 for 3 days, and allowed to recover in room air until pnd60. Mice were treated with l-carnitine (LCT, 150 and 300 mg/kg, i.p.) and baicalin (BLN, 50 and 100 mg/kg, i.p.) daily between pnd4 and pnd13. H&E staining was performed to measure Lm and RAC (A–D), while vWF immunofluorescence was carried out to count vessel numbers in the lung (F–H). Scale bar: 100 μm in A and 50 μm in F. N = 5–10. *P < 0.05, **P < 0.01, ***P < 0.001 vs Air/veh (B, C) or Air (D, E, G, H). †P < 0.05, ††P < 0.01, †††P < 0.001 vs O2/veh using one-way ANOVA followed by Tukey’s multiple comparison test

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