Fig. 10
Endothelial Cpt1a deletion diminished the protective effects of l-carnitine or baicalin against hyperoxia-induced persistent alveolar and vascular simplification. Endothelial cell-specific Cpt1a knockout mice and WT littermates (< 12 h old) were exposed to hyperoxia (95% O2) for 3 days, and allowed to recover in air until pnd60. Mice were treated with baicalin (BLN, 100 mg/kg, i.p.) and l-carnitine (LCT, 300 mg/kg, i.p.) daily between pnd4 and pnd13. H&E staining was performed to measure Lm and RAC (A, B), while vWF immunofluorescence was carried out to count vessel numbers in the lung (C). N = 6–10. *P < 0.05, **P < 0.01, ***P < 0.001 vs corresponding air group. †P < 0.05, ††P < 0.01 vs corresponding O2/Veh. #P < 0.05 vs WT/O2/Veh using one-way ANOVA followed by Tukey's multiple comparison test