Fig. 1
From: NHLRC2 expression is increased in idiopathic pulmonary fibrosis
Immunohistochemical NHLRC2 and collagen α1(IV) chain expression in control lung and idiopathic pulmonary fibrosis (IPF). A A strong cytoplasmic NHLRC2 expression in type II pneumocytes (arrows) and alveolar macrophages (arrowheads) in a control lung. B Normal small airway epithelial cells (arrows) were positive for NHLRC2 while smooth muscle cells (arrowheads) were weakly positive or negative. C In lung tissues of IPF patients, hyperplastic alveolar epithelial cells (arrows) lining fibroblast focus, and some stromal cells (arrowheads) were positive for NHLRC2. D Hyperplastic epithelial cells (arrows) and alveolar macrophages (arrowheads) were positive for NHLRC2 in IPF. E, F Hyperplastic alveolar epithelial cells (arrows) lining honeycombs were strongly positive for NHLRC2. G Stromal cells (arrowheads) of a fibroblast focus were positive for collagen α1(IV) chain, while hyperplastic alveolar epithelial cells (arrows) lining the fibroblast focus were weak or negative in IPF. H Negative control in which primary antibody was substituted with rabbit isotype control. Scale bar 50 µm