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Fig. 9 | Respiratory Research

Fig. 9

From: Knockdown of HSP110 attenuates hypoxia-induced pulmonary hypertension in mice through suppression of YAP/TAZ-TEAD4 pathway

Fig. 9

The molecular mechanism of HSP110 in PH. In PH, the expression of HSP110 is increased in PASMCs, which leads to more HSP110 interacting with YAP and inhibiting YAP/TAZ phosphorylation, and thus promoting YAP/TAZ nuclear translocation. In nucleus, YAP/TAZ binds to transcription factor such as TEAD4 to regulate transcription of target genes involved in cellular proliferation, migration and autophagy. Moreover, TEAD4 could promote the transcriptional activity of HSP110 promoter by binding to the HSP110 promoter in PASMCs

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Respiratory Research

ISSN: 1465-993X

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