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Fig. 2 | Respiratory Research

Fig. 2

From: Knockdown of HSP110 attenuates hypoxia-induced pulmonary hypertension in mice through suppression of YAP/TAZ-TEAD4 pathway

Fig. 2

HSP110 knockdown attenuates the development of PAH induced by hypoxia. The RVSP (a) and RV/(LV + S) ratio (b) of the normoxia and hypoxia groups received with adeno-associated virus-mediated shHSP110 or shNC (N = 8). c H&E staining of pulmonary arteries in lung tissues in each group (N = 8). Scale bars, 50 μm. d Quantification of ratio of pulmonary arterial medial thickness to total vessel size (media/CSA) in each group (N = 8). e Double immunofluorescence staining of α-SMA (green) and PCNA (red) in pulmonary arteries in each group (N = 8). Scale bars, 50 μm. f Quantification of PCNA + cells in pulmonary arteries (N = 8). Data are means ± SD from 8 mice per group. *p < 0.05 compared to the normoxia group. #p < 0.05 compared to the hypoxia-shNC group

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