Deletion of Piezo | Disease | Description | Mechanism |
---|---|---|---|
Nodose ganglia neurons | Impaired Hering-Breuer reflex | Lung over-expansion | Piezo2 transduced the stretch of airway innervating vagal neurons |
Jugular, trigeminal, and DRG neurons | Died within 24Â h after birth | Respiratory distress and smaller airspaces | NA |
NEB | ARDS | Increased fluid in the interstitial and/or alveolar space | Neuropeptide-induced barrier disruption |
Allergic asthma | Promoted smooth muscle contraction, eosinophil infiltration, and goblet cell hyperplasia | PNEC act through CGRP to stimulate ILC2s and elicit downstream immune responses | |
Hippocampus | OSAHS | Decreased the intracranial blood oxygen concentration and damaged hippocampal neurons | NA |