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Table 2 Conditions and mechanisms caused by deletion of Piezo2 ion channel

From: Mechanosensitive Piezo channels mediate the physiological and pathophysiological changes in the respiratory system

Deletion of Piezo

Disease

Description

Mechanism

Nodose ganglia neurons

Impaired Hering-Breuer reflex

Lung over-expansion

Piezo2 transduced the stretch of airway innervating vagal neurons

Jugular, trigeminal, and DRG neurons

Died within 24 h after birth

Respiratory distress and smaller airspaces

NA

NEB

ARDS

Increased fluid in the interstitial and/or alveolar space

Neuropeptide-induced barrier disruption

Allergic asthma

Promoted smooth muscle contraction, eosinophil infiltration, and goblet cell hyperplasia

PNEC act through CGRP to stimulate ILC2s and elicit downstream immune responses

Hippocampus

OSAHS

Decreased the intracranial blood oxygen concentration and damaged hippocampal neurons

NA

  1. CGRP: calcitonin gene-related peptide; ILC2: group 2 innate lymphoid cells; NEB: neuroepithelial body; NA: not applicable; OSAHS: obstructive sleep apnea hypopnea syndrome; PNEC: pulmonary neuroendocrine cells