Table 2 Top differentially expressed genes in CEBPD siRNA versus NT siRNA cells under exposures of control, BUD, TNFα, or BUD + TNFα

CEBPD (CCAAT/enhancer binding protein (C/EBP), delta)

ENSG00000221869

− 1.73

6.40E−54

1086

328

− 1.84

2.20E−30

1578

465

− 1.47

4.70E−14

897

322

− 1.48

2.70E−38

1139

411

TNFRSF10D (tumor necrosis factor receptor superfamily member 10d)

ENSG00000173530

1.47

3.40E−43

1153

3071

1.11

1.20E−21

1126

2053

1.15

8.10E−03

1074

2621

1.11

9.10E−23

918

2045

CDKN1A (cyclin-dependent kinase inhibitor 1A (p21, Cip1))

ENSG00000124762

1.07

6.80E−39

6008

12,477

1.30

6.20E−42

5028

10,959

1.19

4.20E−29

4853

10,939

1.21

8.30E−20

4720

10,733

PDIA4 (protein disulfide isomerase family A member 4)

ENSG00000155660

− 1.69

2.00E−37

3825

1197

− 1.38

4.00E−33

3203

1204

− 1.61

1.30E−44

5132

1686

− 1.66

2.90E−29

4427

1412

RPS15 (ribosomal protein S15)

ENSG00000115268

− 1.25

7.30E−31

2974

1268

− 1.15

2.00E−27

3090

1470

− 1.19

1.50E−53

2745

1201

− 1.37

3.00E−45

2945

1142

DPP4 (dipeptidyl-peptidase 4)

ENSG00000197635

− 1.19

3.20E−26

1877

831

− 1.08

5.00E−15

1882

1124

− 1.18

2.10E−26

3342

1477

− 1.17

9.20E−35

3793

1693

TXNIP (thioredoxin interacting protein)

ENSG00000265972

− 1.37

4.10E−25

3320

1317

− 1.13

3.00E−18

3708

1876

− 1.36

1.40E−37

2387

952

− 1.46

2.70E−21

2544

1018

ELN (elastin)

ENSG00000049540

1.21

3.80E−23

7693

16,628

1.00

5.20E−04

14,062

26,557

1.46

6.70E−29

5276

12,817

1.42

6.90E−33

6815

15,927

VGLL3 (vestigial like family member 3)

ENSG00000206538

− 1.09

1.10E−22

2351

1096

− 0.88

8.60E−09

3369

1924

− 1.00

9.80E−33

2038

1020

− 0.70

3.20E−08

2966

1832

CPM (carboxypeptidase M)

ENSG00000135678

− 1.28

1.30E−18

896

385

− 1.40

2.50E−18

728

237

− 1.39

5.60E−24

1053

407

− 1.26

3.60E−33

1043

440

IGFBP5 (insulin like growth factor binding protein 5)

ENSG00000115461

− 0.58

3.50E−06

251,976

174,891

− 0.36

5.80E−01

179,541

140,387

− 1.02

3.50E−29

253,204

127,426

− 1.06

3.10E−27

165,764

78,967

ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide)

ENSG00000196616

− 2.06

2.70E−04

6291

1905

− 2.18

7.50E−76

11,133

2493

− 2.29

1.10E−04

2143

693

− 1.97

3.20E−05

5099

1540

PRELP (proline/arginine-rich end leucine-rich repeat protein)

ENSG00000188783

− 1.66

7.80E−02

500

142

− 2.35

7.60E−39

657

149

− 1.53

4.20E−02

367

116

− 1.06

3.80E−01

366

223