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Fig. 3 | Respiratory Research

Fig. 3

From: Nintedanib modulates type III collagen turnover in viable precision-cut lung slices from bleomycin-treated rats and patients with pulmonary fibrosis

Fig. 3

Inhibition of C3M and PRO-C3 in the PCLS supernatant from patients with PF. Percentage changes in a C3M and b PRO-C3 concentrations from PCLS incubated with nintedanib compared with PCLS incubated with medium. The EC50 were cal culated with asymmetric (five parameter) least squares fit. Six data points lie outside the plotted axes. C3MC3M neo-epitope of MMP-9 mediated degradation of type III collage n; EC50 half- maxi mal inhibition values; PCLS precision-cut lung slices; PF pulmonary fibrosis; PRO-C3 ADAMTS-2 mediated release of the N-terminal pro-peptid e of type III collagen

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