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Table 3 Secondary Outcomes in the Full Analysis Set After 8 Weeks

From: Effects of treatment with montelukast alone, budesonide/formoterol alone and a combination of both in cough variant asthma

LogC5

M group

BF group

MBF group

Baseline, median (IQR)

1.2 (0.3, 2.4)

(n = 31)

1.8 (1.0, 2.7)

(n = 32)

1.8 (0.7, 2.2)

(n = 32)

Week 4, median (IQR)

1.6 (0.6, 2.7)

(n = 28)

2.4 (1.5, 3.0)

(n = 29)

2.4 (0.9, 3.0)

(n = 32)

Week 8, median (IQR)

2.2 (0.9, 3.0) #

(n = 30)

2.7 (1.8, 3.0) #

(n = 31)

2.4 (1.5, 2.4) #

(n = 32)

Week 4 mean change from baseline, mean (95%CI)

0.3 (− 0.2, 0.8)

(n = 28) p = 0.234

0.3 (− 0.1, 0.8)

(n = 29) p = 0.170

0.5 (0.1, 1.0)

(n = 32) p = 0.064

Week 8 mean change from baseline, mean (95%CI)

0.6 (0.1, 1.0)

(n = 30) p = 0.017

0.5 (0.0, 0.9)

(n = 31) p = 0.033

0.5 (0.1, 1.0)

(n = 32) p = 0.019

Sputum eosinophil, %

   

Baseline, median (IQR)

13.6 (2.0, 37.6)

(n = 32)

16.1 (4.5, 31.5)

(n = 32)

5.8 (1.3, 14.5)

(n = 32)

Week 4, median (IQR)

5.5 (1.0, 26.5) *

(n = 29)

10.0 (2.0, 15.1)

(n = 30)

1.2 (0.5, 8.4)

(n = 28)

Week 8, median (IQR)

4.8 (0.5, 22.3) *

(n = 31)

4.4 (1.5, 12.5) #

(n = 30)

1.0 (0.0, 6.8) #

(n = 31)

Week 4 median change from baseline, median (IQR)

 − 4.3 (− 18.5, − 0.3)

(n = 29) p = 0.002

 − 3.6 (− 22, 0.5)

(n = 30) p = 0.413

 − 4.3 (− 23.0, 2.5)

(n = 28) p = 0.373

Week 8 median change from baseline, median (IQR)

 − 1.5 (− 29.8, 0.3)

(n = 31) p = 0.012

 − 4.3 (− 23.0, 2.5)

(n = 30) p = 0.050

 − 3.0 (− 9.0, − 0.5)

(n = 31) p = 0.023

Geometric mean of FeNO, ppb

   

Baseline, mean (SD)

3.8 ± 1.0

(n = 31)

4.1 ± 0.8

(n = 30)

3.6 ± 0.9

(n = 32)

Week 4, mean (SD)

3.7 ± 0.8

(n = 30)

3.6 ± 0.5 *

(n = 29)

3.1 ± 0.7 *

(n = 32)

Week 8, mean (SD)

3.7 ± 0.8

(n = 30)

3.5 ± 0.7 *

(n = 29)

3.1 ± 0.7 *

(n = 32)

Week 4 mean change from baseline, mean (95%CI)

 − 0.1 (− 0.5, 0.2)

(n = 30) p = 0.416

 − 0.6 (− 0.9, − 0.2)

(n = 29) p = 0.002

 − 0.5 (− 0.8, − 0.1)

(n = 32) p = 0.009

Week 8 mean change from baseline, mean (95%CI)

 − 0.1(− 0.5, 0.2),

(n = 30) p = 0.457

 − 0.6 (− 1.0, − 0.3)

(n = 29) p = 0.001

 − 0.5 (− 0.8, − 0.1)

(n = 32) p = 0.008

  1. Values of LogC5, sputum Eos% and change of sputum Eos% were presented as median (IQR); FeNO was presented as geometric mean. Values of the change in LogC5, FeNO were presented as mean (95%CI) and the change of sputum Eos% was presented as median (IQR). M: montelukast alone; BF: budesonide/formoterol alone; MBF: montelukast plus budesonide/formoterol. FeNO: fractional exhaled nitric oxide; VS baseline: #, p < 0.05; *, p < 0.01