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Table 5 Longitudinal association* between air pollution exposures and parameters of diffusion capacity for visits (n = 1079) done by the participating elderly (n = 543) in this study

From: Air pollution enhance the progression of restrictive lung function impairment and diffusion capacity reduction: an elderly cohort study

 

Dlco

Dlco/VA

VA/TLC*

β (%)

95% CI

P-value

β (%)

95% CI

P-value

β (%)

95% CI

P-value

Model 1: PM2.5

 Cross-sectional

2.31

− 3.39 to 8.35

0.432

0.46

− 4.58 to 5.76

0.859

− 0.04

− 0.23 to 0.15

0.676

 On rate of yearly change

− 0.61

− 2.19 to 0.99

0.454

1.53

0.06 to 3.03

0.042

− 0.09

− 0.16 to − 0.03

0.006

Model 2: NO2

 Cross-sectional

3.38

− 0.3 to 7.19

0.072

1.5

− 1.67 to 4.78

0.357

− 0.04

− 0.18 to 0.11

0.645

 On rate of yearly change

− 1.13

− 2.02 to − 0.23

0.014

0.33

− 0.5 to 1.16

0.439

− 0.08

− 0.12 to − 0.04

0.0002

Model 3: PM2.5 + NO2

 PM2.5

  Cross-sectional

− 0.57

− 7.12 to 6.43

0.868

1.77

− 4.27 to 8.19

0.569

− 0.11

− 0.34 to 0.13

0.362

  On rate of yearly change

0.34

− 1.45 to 2.17

0.710

1.63

0 to 3.28

0.051

− 0.03

− 0.11 to 0.06

0.531

 NO2

  Cross-sectional

1.58

− 4.36 to 7.9

0.609

− 2.34

− 7.48 to 3.08

0.389

0.02

− 0.22 to 0.26

0.863

  On rate of yearly change

− 1.28

− 2.3 to − 0.24

0.016

− 0.07

− 1 to 0.86

0.880

− 0.07

− 0.12 to − 0.02

0.009

  1. Statistically significant (p-value < 0.05), estimates are shown in bold
  2. Dlco diffusing capacity for carbon monoxide, VA alveolar volume, TLC total lung capacity
  3. Adjusted for sex, age at baseline, time from baseline, body height, body weight, current smoke, ex-smoke, pack-years, second-hand smoke, cooking, use of range hood, incense, education, physician diagnosis or treatment for asthma or chronic airway diseases, dusty job history, obstructive ventilation, short-term (lag 1 month) exposure to air pollution, and hospitals
  4. Coefficients were estimated for an interquartile range increase in the exposures to air pollutants (8.13 μg/m3 for PM2.5; 5.37 ppb for NO2)
  5. VA/TLC was calculated for 420 participants with TLC results provided by hospitals