From: Effect of pediatric ventilation weaning technique on work of breathing
Baseline | CPAP/PS | PC-A/C | Baseline | PS -2cmH2O | PS -4cmH2O | PS -6cmH2O | ||
---|---|---|---|---|---|---|---|---|
Clinical parameters | ||||||||
Comfort score | 12 (11–15) | 11 (11–14) | 12 (11–13) | 11 (11–14) | 11 (11–14) | 11 (11–14) | 11 (11–14) | |
Heart rate (beats/min) | 138 (123–149) | 135 (122–149) | 138 (116–150) | 134 (117–144) | 134 (119–142) | 130 (114–149) | 133 (117–150) | |
Peripheral saturation (%) | 98 (95–99) | 97 (95–98) | 98 (96–98) | 97 (95–98) | 97 (95–98) | 96 (94–98) | 97 (96 -100) | |
Respiratory rate (/min) | 37 (26–48) | 35 (22–48) | 32 (23–43)* | 37 (21–48) | 36 (23–53)* | 37 (30–53)* | 35 (27–53) | |
Respiratory parameters | ||||||||
Expired tidal volume (ml) | 41.1 (27.9–82.9) | 41.9 (26.2–85.7) | 43.8 (26.1–88.2) | 41.1 (24.8–79.9) | 38.2 (22.2–69.6)* | 34.6 (23.7–74.8)* | 36.5 (28.2–73.4) | |
End tidal CO2 (mmHg) | 49.4 (45.9–54.5) | 49.05 (43.7–54.9) | 48.8 (45.1–53.4) | 49.7 (44.8–52.5) | 49.3 (45.6–53.5) | 49.4 (44.7–56.3) | 53.0 (46.7–55.8)* | |
Tinsp | 0.50 (0.43–0.67) | 0.52 (0.39–0.69) | 0.63 (0.44–0.73)* | 0.52 (0.40–0.76) | 0.49 (0.38–0.68)* | 0.51 (0.41–0.63) | 0.53 (0.43–0.69) | |
RSBI | 0.88 (0.33–1.64) | 0.78 ( 0.31–1.70) | 0.61 (0.29–1.50)* | 0.80 (0.28–1.74) | 1.00 (0.33–2.09)* | 1.10 (0.40–2.09) | 0.88 (0.36–2.07)* | |
Ventilator settings | ||||||||
Fraction inspired oxygen (%) | 30 (26–39) | 30 (26–39) | 30 (26–39) | 30 (25–40) | 30 (27–40) | 30 (27–40) | 30 (27–40) | |
PEEP (cmH2O) | 6 (5–6) | 6 (5–6) | 6 (5–6) | 6 (5–6) | 6 (5–6) | 6 (5–6) | 6 (5–6) | |
PS (cmH2O)1 | 14 (12–16) | 14 (12–16) | 14 (12–16) | 14 (12–16) | 12 (10–14) | 10 (8–12) | 8 (6–10) | |
Metrics of oxygenation and ventilation | ||||||||
PaO2 (mmHg) | 76.51 (66.68–87.76) | 74.93 (66.54–85.89) | 76.51 (67.21–86.26) | No blood samples withdrawn | ||||
PaCO2 (mmHg) | 50.10 (56.25–46.50) | 50.18 (45.00–5.28) | 51.75 (47.25–54.98) | |||||
Oxygenation index | 4.92 (3.79–6.03) | 4.33 (3.72–5.82) | 4.63 (3.79–5.74) | |||||
PF ratio | 257 (181–295) | 228 (185–278) | 249 (192–287) |