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Table 2 Clinical characteristics of CVA, CPA and CA

From: Characteristics of different asthma phenotypes associated with cough: a prospective, multicenter survey in China

Variable

Total

CVA

CPA

CA

p

Number

2088

327

1041

720

–

Age, years

45.4 ± 14.5

43.5 ± 15.7*#

45.8 ± 14.3

46.0 ± 14.0

0.016

Female, n (%)

1254 (60.1)

204 (62.4)#

644 (61.9)#

406 (56.4)

0.045

BMI kg/m2

23.3 ± 3.6

22.8 ± 3.6

23.4 ± 3.7

23.6 ± 3.5&

0.017

Asthmatic duration, month

24.5 (7.0, 96.0)

12.0 (3.5, 36.0)*#

24.0 (6.0, 84.0)&#

48.0 (12.0, 120.0)&*

< 0.001

Non-smoker, n (%)

1632 (78.2)

289 (88.4)*#

812 (78.0)

531 (73.8)

< 0.001

Ex-smoker, n (%)

101 (4.8)

4 (1.2)*#

56 (5.4)

41 (5.7)

< 0.001

Current smoker, n (%)

355 (17)

34 (10.4)#

173 (16.6)#

148 (20.6)

< 0.001

Blood Eos (109/L)

0.2 (0.1, 0.5)

0.3 (0.1, 0.4)

0.3 (0.1, 0.5)

0.2 (0.1, 0.4)

0.312

With regular treatment† within the past 3 months, n (%)

549 (26.3)

34 (10.4)*#

274 (26.3)&#

241 (33.5)&*

< 0.001

Number of patients with cough, n (%)

1851 (88.6)

327 (100)

1041 (100)

483 (67.1)

NS

Dry cough, n (%)

1045/1851 (56.5)

222/327 (67.9)*

544/1041 (52.3)

279/483 (57.8)

< 0.001

Day cough, n (%)

1079/1851 (58.3)

235/327 (71.9)*#

579/1041 (55.6)

266/483 (55

< 0.001

Night cough, n (%)

1505/1851 (81.3)

258/327 (78.9)

869/1041 (83.5)

378/483 (78.3)

0.312

Cough as the initial symptom, (n) %

1356 (64.9)

327 (100)

803 (77.1)

226 (31.4)*

< 0.001

Time from cough to wheeze ^, month

–

–

3.0 (1.0,12.0)#

2.0 (1.0, 8.0)

0.032

Lung function, n

1913

314

961

638

NS

FEV1% pred

78.8 ± 20.7

92.6 ± 12.8*#

77.8 ± 20.8&#

73.7 ± 20.8&*

< 0.001

FVC% pred

92.9 ± 17.6

96.5 ± 14.9*#

92.6 ± 18.5

91.7 ± 17.2

< 0.001

FEV1/FVC%

70.8 ± 13.2

80.7 ± 7.9*#

70.0 ± 12.6&#

67.0 ± 13.7&*

< 0.001

MMEF% pred

48.5 ± 24.9

66.4 ± 21.6*#

46.4 ± 23.8&#

43.0 ± 24.0&*

< 0.001

  1. Data were presented as percentage or mean SD or median (IQR)
  2. CVA: Cough variant asthma; CPA: Cough predominant asthma; CA: Classic asthma; BMI: body mass index; FEV1% pred: forced expiratory volume in 1 s in % predicted; FVC% pred: forced vital capacity in % predicted; MMEF% pred: the maximum mid-expiratory flow in % predicted
  3. †Inhaled corticosteroids (ICS)/ICS + long-acting Beta2-agonists (LABA)
  4. ^How long the patient developed wheezing after developing cough as the initial symptom of asthma onset in CPA and CA patients
  5. &Compared to CVA, p < 0.05
  6. *Compared to CPA, p < 0.05
  7. #Compared to CA, p < 0.05