Fig. 4

Relative proteomic quantification of differently regulated proteins in V79 cell treatments and their bioinformatics comparison. A Heat map of relative, label-free protein quantification (LFQ) of V79 cell line treatments displaying the protein groups that passed the filters (only significantly up- and downregulated proteins in respect to control, at p < 0.01 done with PEAKS Q statistical test). The hierarchical clustering was generated using neighbour-joining algorithm with a Euclidean distance similarity measurement of the log2 ratios of the protein abundance of each group relative to the average abundance. B Gene ontologies with significant enrichment (p < 0.05, according to a hypergeometric and Bonferroni tests) in control-upregulated (red bars) and control-downregulated (green bars) proteins, in respect to molecular function, cellular component and biological processes aspects done in FunRich 3.1.3 program