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Fig. 3 | Respiratory Research

Fig. 3

From: Platelet-derived growth factor (PDGF)-BB regulates the airway tone via activation of MAP2K, thromboxane, actin polymerisation and Ca2+-sensitisation

Fig. 3

(Human and GPs’ PCLS): PDGF-BB regulates the airway tone via activation of PDGFR-(β). A The contractile effect of PDGF-BB in GPs’ airways: (◆) no pre-treatment/100 nM PDGF-BB (n = 7); ( ) pre-treatment with 100 nM ponatinib/100 nM PDGF-BB (n = 7); (◇) pre-treatment with 5 µM SU6668/100 nM PDGF-BB (n = 7). B PDGF-BB contracts human airways: (◆) 100 nM PDGF-BB (n = 3); (◇) pre-treatment with 100 µM imatinib/100 nM PDGF-BB (n = 3). C Imatinib relaxes human airways: (△) pre-treatment with 100 nM ET-1 (n = 3); (▲) pre-treatment with 100 nM ET-1/imatinib (n = 5). A, B Statistics was performed by a LMM. C Statistics was performed by calculating EC50 values by the standard 4-parameter logistic non-linear regression model (GraphPad). p < 0.05 are considered as significant: *p < 0.05, **p < 0.01 and ***p < 0.001

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