Table 4 Initial nasal transcriptomic subgroup comparisons
From: Multi-omic characterization of pediatric ARDS via nasal brushings
Levels | A (n = 9) | B (n = 7) | C (n = 17) | D (n = 5) | p-value | |
|---|---|---|---|---|---|---|
Age | Median (IQR) | 5.2 (4.8 to 11.0) | 9.0 (3.2 to 10.3) | 7.9 (4.4 to 8.6) | 5.3 (5.1 to 8.0) | 0.96 |
Sex | Female | 5 (55.6) | 3 (42.9) | 7 (41.2) | 2 (40.0) | 0.96 |
Male | 4 (44.4) | 4 (57.1) | 10 (58.8) | 3 (60.0) | ||
Race | Non-White | 1 (11.1) | 3 (42.9) | 6 (35.3) | 1 (20.0) | 0.528 |
White | 8 (88.9) | 4 (57.1) | 11 (64.7) | 4 (80.0) | ||
Genetic Synd. or D.D | False | 6 (66.7) | 1 (14.3) | 6 (35.3) | 2 (40.0) | 0.20 |
True | 3 (33.3) | 6 (85.7) | 11 (64.7) | 3 (60.0) | ||
Baseline lung disease | False | 7 (77.8) | 4 (57.1) | 11 (64.7) | 4 (80.0) | 0.82 |
True | 2 (22.2) | 3 (42.9) | 6 (35.3) | 1 (20.0) | ||
Immunocompromised | False | 6 (66.7) | 4 (57.1) | 12 (70.6) | 3 (60.0) | 0.96 |
True | 3 (33.3) | 3 (42.9) | 5 (29.4) | 2 (40.0) | ||
Highest PELOD2 | Median (IQR) | 12.0 (11.0 to 15.0) | 12.0 (11.0 to 14.5) | 12.0 (10.0 to 14.0) | 15.0 (14.0 to 15.0) | 0.71 |
Highest PARDS category | None | 1 (11.1) | 0 (0.0) | 0 (0.0) | 1 (20.0) | 0.66 |
Mild | 2 (22.2) | 0 (0.0) | 5 (29.4) | 1 (20.0) | ||
Moderate | 4 (44.4) | 4 (57.1) | 8 (47.1) | 2 (40.0) | ||
Severe | 2 (22.2) | 3 (42.9) | 4 (23.5) | 1 (20.0) | ||
Viral infection | False | 4 (44.4) | 3 (42.9) | 11 (64.7) | 2 (40.0) | 0.64 |
True | 5 (55.6) | 4 (57.1) | 6 (35.3) | 3 (60.0) | ||
Any corticosteroids | No | 3 (33.3) | 2 (28.6) | 7 (41.2) | 3 (60.0) | 0.769 |
Yes | 6 (66.7) | 5 (71.4) | 10 (58.8) | 2 (40.0) | ||
Ventilator free days | Median (IQR) | 21.8 (19.4 to 24.5) | 13.0 (0.0 to 18.1) | 18.9 (12.9 to 21.3) | 17.9 (0.0 to 22.4) | 0.082 |
PICU days | Median (IQR) | 20.0 (15.0 to 29.0) | 25.0 (17.5 to 61.5) | 15.0 (10.0 to 22.0) | 8.0 (7.0 to 24.0) | 0.294 |
Hospital days | Median (IQR) | 45.0 (28.0 to 103.0) | 31.0 (25.0 to 107.5) | 20.0 (13.0 to 45.0) | 13.0 (12.0 to 56.0) | 0.182 |
Mortality | Died | 2 (22.2) | 2 (28.6) | 2 (11.8) | 1 (20.0) | 0.774 |
Survived | 7 (77.8) | 5 (71.4) | 15 (88.2) | 4 (80.0) |