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Fig. 6 | Respiratory Research

Fig. 6

From: Multi-omic characterization of pediatric ARDS via nasal brushings

Fig. 6

Functional epigenetic modules in PARDS. A We compared genes that had coordinate hypomethylation and increased expression or vice versa and combined each Methyl and Nasal Transcriptomic Subgroup to make a combined subgroup. Gene sets with coordinate epigenetic and transcriptional changes were termed functional epigenetic modules and used in gene set enrichment analysis. Combined subgroup B2 had changes in genes related to downstream inflammatory signaling. B Genes that encode for cell–cell and cell–matrix interface proteins had coordinate changes in methylation and gene expression in multiple combined subgroups

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