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Table 4 Univariate and multivariate analysis of predictors of mortality and lung transplantation

From: Characterization of the PF-ILD phenotype in patients with advanced pulmonary sarcoidosis

 

N

Univariate analysis for overall mortality and lung transplantation

Multivariate analysis for overall mortality and lung transplantation

HR

95% CI

P-value

HR

95% CI

P-value

Age

106

1.0

1.0–1.1

0.127

   

Gender (male)

106

1.6

0.5–4.8

0.437

   

Ethnicity: white

96

0.4

0.1–1.1

0.070

   

Smoking

Ex

100

1.5

0.5–4.2

0.441

   

Current

100

5.0

0.6–38.2

0.124

   

CPI

104

1.1

1.0–1.1

0.049

1.0

1.0–1.1

0.256

PH

106

3.8

1.0–14.3

0.047

4.6

1.1–20.3

0.042

PF-ILD

94

4.5

1.6–12.5

0.004

4.5

1.5–13.7

0.008

Scadding stage IV

100

1.5

0.5–4.0

0.451

   

Total disease extension

106

1.0

1.0–1.0

0.438

   

% Fibrosis

106

1.0

1.0–1.1

0.062

   

% Groundglass

106

1.0

1.0–1.0

0.090

   

% Other pattern

106

1.0

1.0–1.0

0.761

   

MPA/AAD ratio

103

3.2

0.2–58.0

0.429

   

Emphysema

106

1.0

0.3–3.1

0.987

   

Traction bronchiectasis

106

1.3

0.5–3.3

0.627

   

UIP like pattern

106

9.8

2.6–36.6

0.001

13.1

3.1–54.6

< 0.001

MUC5B; carriers of T allele

106

0.6

0.2–2.1

0.442

   

Walsh poor prognosis

106

22.6

0.0–190

0.465

   
  1. HR = hazard ratio; 95% CI = 95% confidence interval; CPI = composite physiological index; PF-ILD = progressing fibrotic interstitial lung disease; MPAd/AAd = mean pulmonary artery diameter/ascending aorta diameter; UIP = usual interstitial pneumonia; MUC5B = Mucin5B; PH = pulmonary hypertension