Association of childhood BMI trajectory with post-adolescent and adult lung function is mediated by pre-adolescent DNA methylation

Table 3 Associations of DNAm with expression of mapped genes within 500k bps

Sex	CpG	Gene*	DNAm effect	SE	p-value	Approximate distance between CpG site and gene (in bps)
Males	cg21883115^#	LARP7	0.9	0.36	0.014	165–183k
	cg15628222	LINC00469	2.11	0.82	0.014	232–246k
		*TRAM1*	0.87	0.47	0.072	33
	cg15594471^#	CWC15	0.52	0.13	0.0003	175–187k
	cg10337540	KLHL11	1.54	0.68	0.029	45–60k
	cg06710672^#	TRIP13	− 0.54	0.25	0.033	215–241k
	cg00509207^#	DDX11	1.45	0.70	0.044	147–178k
Females	cg00647820	CHRNA9	− 0.75	0.31	0.019	76–96k
	cg02710571^#	SUSD4	− 0.71	0.30	0.020	229–242k
	cg04206296	CNIH4	0.22	0.09	0.019	172–196k
		*DEGS1*	0.17	0.09	0.071	7–97
	cg09005221^#	DYNLRB2	− 0.99	0.33	0.004	92–103k
	cg13314614	PARVA	1.12	0.40	0.006	102–245k
		*DHRS3*	0.66	0.23	0.006	23–25
	cg14654082	TMEM88	0.69	0.28	0.016	37–39k
	cg14880800^#	COX10	0.33	0.15	0.030	25–165k
	cg17023770^#	SLC25A36	0.52	0.24	0.030	34–71k
	cg18164362^#	EFCAB1	− 1.99	0.88	0.026	224–244k
	cg20015855	AUTS2	− 1.02	0.28	0.0004	125–242k
	cg21909286^#	ARHGAP42	− 1.03	0.42	0.016	73–220k
	cg26606556	MAST1	− 1.07	0.40	0.008	62–96k
		*FARSA*	− 0.58	0.17	0.001

For each CpG, the neighboring gene with the largest absolute value of regression coefficient was shown along with their mapping genes if the p-value is (marginally) significant. The full list of CpGs is in Additional file 1: Table S3
*Genes in first row are the nearby genes with largest absolute effect size and genes in second row (in bold font) for same CpG is its corresponding mapped gene
^#Gene expression data was not available for mapping genes at these CpGs

ISSN: 1465-993X