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Table 3 Summary clinical findings for meta-analysis and descriptive review cohorts

From: Effect size of rituximab on pulmonary function in the treatment of connective-tissue disease-related interstitial lung disease: a systematic review and meta-analysis

Meta-analysis (N = 14 studies)

Age (mean age ± SD)

Sex (F/M)

Disease type

ILD (fibrotic vs non-fibrotic)

Rationale for initiating RTX

52 ± 7

184/77 (not delineated in two studies (N = 35))

SSc = 120

RA = 98

ASS = 22

SS = 12

SLE = 7

IIM = 8

Unclassifiable = 4

Fibrotic = 290*

OP = 3

Nodular or GGO = 4

Non-response to prior therapy = 260

Firstline = 3

Randomized = 33

Descriptive analysis (N = 6 studies)

Age (mean age)

Sex (F/M)

Disease type

ILD (fibrotic vs non-fibrotic)

Rationale for initiating RTX

56 ± 3

41/34 (not delineated in one study (N = 31))

SSc = 3

RA = 39

ASS = 52

IIM = 3

MCTD = 2

Unclassifiable = 1

Fibrotic = 95*

OP = 2

LIP = 1

Unclassified = 1

Non-response to prior therapy = 62

Firstline = 7

(Not delineated in 2 studies (N = 38))

  1. ASS  antisynthetase syndrome, F female, GGO  ground glass opacities, IIM idiopathic inflammatory myopathy, ILD interstitial lung disease LIP lymphocytic interstitial pneumonia, M male, MCTD mixed connective tissue disease, OP organizing pneumonia, RTX rituximab, RA rheumatoid arthritis, SLE systemic lupus erythematosus, SSc scleroderma or systemic sclerosis, SD standard deviation
  2. *Inclusive of mixed fibrotic and GGO infiltrates, usual interstitial pneumonia, nonspecific interstitial pneumonia (NSIP), and NSIP with organizing pneumonia