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Fig. 5 | Respiratory Research

Fig. 5

From: Deficiency of leukocyte-specific protein 1 (LSP1) alleviates asthmatic inflammation in a mouse model

Fig. 5

The histopathological examination of mouse lungs with hematoxylin and eosin staining. Control wildtype A and Lsp1−/− mice B display normal appearing alveolar septa and alveoli. In comparison to Lsp1−/− OVA lungs (D), WT OVA mouse lungs C showed more inflammatory cell infiltration in alveolar septa, alveoli, and peri-bronchial and peri-vascular spaces. E Semi-quantitative scoring showed more severe pathology in WT OVA and Lsp1−/− OVA mice than in their respective control controls, and more in WT OVA mice, than in Lsp1−/− OVA mice. F The analysis of protein concentration in BAL fluid showed that both types of mice challenged with OVA had significantly higher protein concentration than control but there was no significant difference between WT and Lsp1−/− mice. As Alveolar space, Bv Blood vessel, Br Bronchiole, PVS Peribronchiolar vascular space, WT wildtype. Magnification: 400 × . Asterisk (*) indicates a significant difference (P < 0.05, n = 6 each group)

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