Fig. 4

Knocking-out LSP1 ameliorated AHR in the OVA-induced asthma mouse model. Statistical linear regression shows that the slopes of the AHR curves for the WT OVA mice (Y = − 1.958*X–19.48) and Lsp1^−/− OVA mice (Y = − 1.206*X–22.79) are significant different (P < 0.05, n = 6 each group). It suggested that the AHR of Lsp1^−/− OVA mice was improved compared with that of WT OVA mice. Data expressed as mean ± SEM at each methacholine dose