Fig. 1
From: Deficiency of leukocyte-specific protein 1 (LSP1) alleviates asthmatic inflammation in a mouse model
The increased expression of LSP1 in asthma mouse lungs. LSP-1 staining is observed in lung sections from control mouse A and OVA-challenged mouse lungs (B). The staining is observed in bronchiolar epithelium, and endothelium (arrows). High magnification insets in A and B show staining in alveolar macrophages (Magnification: 400 × and 1000 ×). C The representative confocal images of OVA mouse lung sections show staining for LSP-1 (green) and myeloperoxidase (MPO; red). The merged image show LSP-1 to be predominantly in neutrophils. Western blots D and the densitometry E for LSP1 (at about 52 kD) and β-actin (47 kD) showed that OVA mouse lungs have higher LSP1 levels than control mouse lungs. Data were expressed as mean ± SEM. Asterisk (*) indicates significant difference from wildtype control (P < 0.05, n = 3 each group). As alveolar space, Bv blood vessel, Br bronchiole, N Neutrophil, WT wildtype