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Table 3 Association of the IPF and ILA [IPF transcripts] scores with time-to-death in the COPDGene test set (n = 735) and ECLIPSE (n = 571)

From: Blood gene expression risk profiles and interstitial lung abnormalities: COPDGene and ECLIPSE cohort studies

Score

Cohort

Stratum

Unadjusted

Adjusted

HR (95% CI)

p

HR (95% CI)

p

c-index

IPF score

COPDGene test set

All

1.3 (0.71–2.3)

0.41

1.3 (0.7–2.3)

0.44

0.63

ILA

1.3 (0.47–3.8)

0.6

1.2 (0.44–3.6)

0.68

0.66

non-ILA

1.2 (0.57–2.4)

0.67

1.2 (0.58–2.4)

0.63

0.61

ECLIPSE

All

1.3 (0.77–2.1)

0.36

1.2 (0.75–2)

0.4

0.56

ILA

2.2 (0.49–10)

0.3

2.6 (0.54–13)

0.23

0.54

non-ILA

1.2 (0.72–2.1)

0.47

1.2 (0.7–2)

0.54

0.56

ILA score [IPF transcripts]

COPDGene test set

All

1.4 (1.2–1.7)

3.60E-05

1.3 (1.1–1.6)

0.0012

0.64

ILA

1 (0.64–1.6)

0.99

0.9 (0.53–1.5)

0.69

0.66

non-ILA

1.6 (1.3–2)

2.50E-06

1.6 (1.3–2)

4.00E-05

0.62

ECLIPSE

All

1.3 (1.1–1.4)

0.003

1.2 (1–1.4)

0.023

0.6

ILA

1.2 (0.78–1.7)

0.47

1.1 (0.67–1.7)

0.82

0.52

non-ILA

1.3 (1.1–1.5)

0.006

1.2 (1–1.4)

0.027

0.59

  1. Multivariable Cox regression models were adjusted for age, sex, race, body-mass index, pack-years of smoking, and current smoking status. ILA = interstitial lung abnormalities. C-indices for multivariable models including clinical variables and corresponding risk score are shown in the right-hand column