Skip to main content

Table 2 Odds ratios of the IPF and ILA [IPF transcripts] risk scores with ILA in the COPDGene test set (n = 735) and ECLIPSE (n = 571)

From: Blood gene expression risk profiles and interstitial lung abnormalities: COPDGene and ECLIPSE cohort studies

Score

COPDGene

ECLIPSE

Combined (Meta-analyses)

Unadjusted

 

Adjusted

 

Unadjusted

 

Adjusted

 

Adjusted

 

OR (95% CI)

p

OR (95% CI)

p

OR (95% CI)

p

OR (95% CI)

p

OR (95% CI)

p

IPF score

1.8 (1.1–2.8)

0.018

1.7 (1.1–2.8)

0.023

0.64 (0.22–1.9)

0.41

0.63 (0.22–1.8)

0.4

1.5 (0.95—2.3)

0.083

ILA score [IPF transcripts]

1.4 (1.2–1.7)

6.70E-05

1.3 (1.1–1.6)

0.0019

1.5 (1.2–2)

0.001

1.4 (1.1–1.9)

0.011

1.4 (1.2—1.6)

6.80E-05

  1. Logistic regression models were adjusted for age, sex, race, body-mass index, pack-years of smoking, and current smoking status. Inverse variance fixed-effects meta-analyses of the adjusted estimates were performed
  2. ILA interstitial lung abnormalities, IPF idiopathic pulmonary fibrosis