Fig. 5

Metabolic pathway analysis. Metabolic pathway changes in serum between A community-acquired pneumonia (CAP) with and without acquired respiratory distress syndrome (ARDS) groups; and B before and after treatment in the CAP with ARDS group. Metabolic pathway changes in urine between C CAP with and without ARDS groups; and D before and after treatment in the CAP with ARDS group. The yellow or green shades represent significantly increased and decreased levels of metabolites, respectively. E Correlation heatmap of metabolites with clinical parameters in the community-acquired pneumonia with acute respiratory distress syndrome. Only correlation coefficients > 0.4 (moderate correlation) and p-values > 0.05 are highlighted. Red and blue colors indicate positive and negative correlations, respectively, with darker colors indicating higher correlations. Cho choline, Gly glycine, Glc glucose, Pyr pyruvate, Lac lactate, Ile isoleucine, Leu leucine, Ala alanine, 3-HB 3-hydroxybutyrate, CoA coenzyme A, Aca acetoacetate, Acn acetone, TCA tricarboxylic acid, Cit citrate, Cre creatine, Crea creatinine, Nin nicotinate; Nim nicotinamide, 1-Mnim 1-methylnicotinamide; TC total cholesterol, LDL low-density lipoprotein, WBC white blood cell; NEUT#, absolute neutrophil count; LYMPH#, absolute lymphocyte count, Hb hemoglobin, PLT platelet, TBIL total bilirubin, AST aspartate aminotransferase, TP total protein, ALB albumin, BUN blood urea nitrogen, SCR serum creatinine; GLC, glucose; CK creatine kinase, LDH lactate dehydrogenase; CRP C-reactive protein, ESR erythrocyte sedimentation rate, PCT procalcitonin, IL interleukin, IFN interferon, CD4 cluster of differentiation 4; CD8 cluster of differentiation 8