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Table 4 Distribution of frequent genotypes according to the background disease an geographical areas

From: Feasibility of a genotyping system for the diagnosis of alpha1 antitrypsin deficiency: a multinational cross-sectional analysis

Diseases

Frequent genotypes

Argentina

Brazil

Chile

Colombia

LATAM

Spain

Turkey

Total

COPD

n

1234

1909

1189

1936

6268

7025

1936

15,229

MS

126 (10.2)

249 (13.0)

100 (8.4)

185 (9.6)

660 (10.5)

1337 (19.0)

7 (0.4)

2004 (13.2)

MZ

35 (2.8)

83 (4.3)

13 (1.1)

13 (1.1)

153 (2.4)

483 (6.9)

34 (1.8)

670 (4.4)

SS

7 (0.6)

15 (0.8)

2 (0.2)

2 (0.2)

32 (0.5)

180 (2.6)

0 (0)

212 (1.4)

SZ

5 (0.4)

13 (0.7)

1 (0.1)

1 (0.1)

24 (0.4)

140 (2.0)

0 (0)

164 (1.1)

ZZ

4 (0.3)

42 (2.2)

2 (0.2)

2 (0.1)

52 (0.8)

74 (1.1)

6 (0.3)

132 (0.9)

Poorly controlled asthma

n

682

183

325

61

1251

2095

35

3381

MS

62 (9.1)

20 (10.9)

28 (8.6)

5 (8.2)

115 (9.2)

409 (19.5)

0 (0)

524 (15.5)

MZ

15 (2.2)

9 (4.9)

4 (1.2)

1 (1.6)

29 (2.3)

155 (7.4)

1 (2.9)

185 (5.5)

SS

2 (0.3)

2 (1.1)

1 (0.3)

0 (0)

5 (0.4)

65 (3.1)

0 (0)

70 (2.1)

SZ

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

37 (1.8)

0 (0)

37 (1.1)

ZZ

0 (0)

1 (0.5)

0 (0)

1 (1.6)

2 (0.2)

19 (0.9)

1 (2.9)

22 (0.7)

Bronchiectasis

n

127

267

155

76

625

777

33

1435

MS

5 (3.9)

39 (14.6)

16 (10.3)

7 (9.2)

67 (10.7)

154 (19.8)

0 (0)

221 (15.4)

MZ

7 (5.5)

11 (4.1)

2 (1.3)

0 (0)

20 (3.2)

81 (10.4)

1 (3.0)

102 (7.1)

SS

0 (0)

5 (1.9)

1 (0.6)

0 (0)

6 (1.0)

36 (4.6)

0 (0)

42 (2.9)

SZ

0 (0)

4 (1.5)

0 (0)

0 (0)

4 (0.6)

22 (2.8)

0 (0)

26 (1.8)

ZZ

0 (0)

9 (3.4)

0 (0)

0 (0)

9 (1.4)

18 (2.3)

0 (0)

27 (1.9)

Panniculitis or multiorgan vasculitis of unknown cause

n

8

14

0

0

22

16

1

41

MS

1 (12.5)

2 (14.3)

0 (0)

0 (0)

3 (12.5)

3 (18.8)

0 (0)

6 (14.6)

MZ

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

1 (6.3)

0 (0)

1 (2.4)

SS

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

SZ

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

ZZ

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

  1. Data expressed as absolute numbers with percentages in parenthesis; showing percentages referred to the total number of samples in the geographical area with that particular disease