Fig. 10
From: Autophagy regulates the effects of ADSC-derived small extracellular vesicles on acute lung injury
Autophagy mediates the miRNA expression profile of ADSC-sEVs. The expression of let-7-a-1, miR-21a, miR-143, miR-145a and miR-451a in ADSC-sEVs. IL-1β treatment increased the expression of miR-21a and decreased that of let-7-a-1, miR-143 and miR-145a but did not affect the expression of miR-451a. Interestingly, autophagy inhibition weakened the expression of all these miRNAs under IL-1β stimulation. The results are expressed as the mean ± SD of three independent experiments (fold change of let-7-a-1, control, 1.00 ± 0.05 vs. ADSCIL−1β-sEV, 0.71 ± 0.10 vs. ADSCIL−1β+siATG5-sEV, 0.58 ± 0.08. fold change of miR-21a, control, 1.00 ± 0.06 vs. ADSCIL−1β-sEV, 1.23 ± 0.09 vs. ADSCIL−1β+siATG5-sEV, 0.89 ± 0.17. fold change of miR-143, control, 1.00 ± 0.12 vs. ADSCIL−1β-sEV, 0.69 ± 0.05 vs. ADSCIL−1β+siATG5-sEV, 0.49 ± 0.13. fold change of miR-145a, control, 1.00 ± 0.04 vs. ADSCIL−1β-sEV, 0.74 ± 0.04 vs. ADSCIL−1β+siATG5-sEV, 0.44 ± 0.15. fold change of miR-451a, control, 1.01 ± 0.19 vs. ADSCIL−1β-sEV, 0.99 ± 0.16 vs. ADSCIL−1β+siATG5-sEV, 0.67 ± 0.21)