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Fig. 2 | Respiratory Research

Fig. 2

From: Blocking P2X purinoceptor 4 signalling alleviates cigarette smoke induced pulmonary inflammation

Fig. 2

Inhibition of P2RX4-mediated signalling alleviates CS-induced airway inflammation in mice. Differential cell counts as well as concentrations of proinflammatory cytokines (CXCL1/KC, MCP-1, IL-1ß, IL-6) in the BALF of mice a, b treated with 10 µM 5-BDBD 30 min prior each daily smoke exposure, and c, d deficient for P2rx4 (P2rx4−/−) after cigarette smoke (CS) exposure for three consecutive days compared to untreated (Vehicle/CS) or wild type (P2rx4+/+) animals, respectively. Data is presented as individual symbols (n = 6–7) and mean + SD. Treatment data was analysed applying Welch’s ANOVA corrected for multiple comparison using Dunett’s T3 test. Deficiency data was analysed applying two-way ANOVA corrected for multiple comparison using Tukey test. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001

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