Digital quantification of p16-positive foci in fibrotic interstitial lung disease is associated with a phenotype of idiopathic pulmonary fibrosis with reduced survival

Table 5 Top 5 gene-sets significantly enriched in the fibroblastic foci vs. fibrotic areas (GSEA)

Gene Set	NES	q value
Cadherin binding	2.40	0.012
Structural molecular activity	2.36	0.016
Extracellular matrix structural constituent conferring tensile strength	2.34	0.020
Abnormality of limb epiphysis morphology	2.29	0.034
Extracellular matrix structural constituent	2.27	0.046

The positive enrichment score indicated a correlation with the fibroblastic foci microenvironment group
NES normalized enrichment score
q value: false discovery ratio

ISSN: 1465-993X