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Fig. 6 | Respiratory Research

Fig. 6

From: Digital quantification of p16-positive foci in fibrotic interstitial lung disease is associated with a phenotype of idiopathic pulmonary fibrosis with reduced survival

Fig. 6

Normalized mRNA expression of CDK 4/ 6 inhibitors (A), matrix remodelling genes (B) and collagens (C) in fibroblastic foci (orange, n = 12), areas of dense fibrosis (red, n = 6), and areas of normal lung (green, n = 6) in tissue with a high density of p16-positive foci. Expression of p21, MMP1, MMP11, ADAM12, COL1A1, COL1A2, and COL3A1 are increased in fibroblastic foci when compared to areas of dense fibrosis and areas of normal lung

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