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Fig. 5 | Respiratory Research

Fig. 5

From: Digital quantification of p16-positive foci in fibrotic interstitial lung disease is associated with a phenotype of idiopathic pulmonary fibrosis with reduced survival

Fig. 5

Heat map representing differentially expressed genes (fold change ≥ 1.5 and q value < 0.05) and hierarchic clustering based on 97 differentially expressed genes. Each row corresponds to an individual lung microenvironment, and each column corresponds to an individual gene. Each square on the matrix represents the expression level of an individual gene in each sample, with red and green indicating gene expression levels above or below, respectively, compared with each other. Relative levels of mRNA expression are illustrated with green (relative decrease, up to − 1), red (relative increase, up to + 1) or no change (black, 0). Unsupervised clustering analysis shows distinct homology of expression within the fibroblastic foci, divergent from the expression patterns within the areas of normal lung and dense fibrosis

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Respiratory Research

ISSN: 1465-993X

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