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Table 3 Risk factors for all-cause mortality in patients with RA-ILD

From: Pleuroparenchymal fibroelastosis in rheumatoid arthritis-associated interstitial lung disease

Variables

Unadjusted analysis

Multivariable analysis

HR

95% CI

p-value

HR

95% CI

p-value

Age

1.050

1.032–1.069

 < 0.001

1.046

1.026–1.066

 < 0.001

Men

1.908

1.375–2.648

 < 0.001

1.919

0.964–3.819

0.063

Ever-smoker

1.543

1.113–2.138

0.009

0.799

0.400–1.596

0.525

BMI

0.953

0.903–1.005

0.074

   

FVC

0.983

0.974–0.992

 < 0.001

0.986

0.973–1.004

0.031

DLCO

0.985

0.976–0.993

0.001

0.993

0.982–1.004

0.206

TLC

0.985

0.973–0.996

0.009

   

RV

0.996

0.986–1.005

0.360

   

UIP-like pattern on HRCT

2.404

1.383–4.177

0.002

2.186

1.166–4.099

0.015

PPFE

1.433

0.727–2.823

0.299

   

Extensive PPFEa

2.322

1.080–4.995

0.031

1.618

0.743–3.523

0.226

Corticosteroid ± IM

1.052

0.734–1.506

0.783

   
  1. We did not include TLC in the multivariable model, as it strongly correlated with FVC (correlation coefficient, r = 0.895; p < 0.001)
  2. RA rheumatoid arthritis, ILD interstitial lung disease, HR hazard ratio, CI confidence interval, BMI body mass index, FVC forced vital capacity, DLco diffusing capacity for carbon monoxide, TLC total lung capacity, RV residual volume, UIP usual interstitial pneumonia, PPFE pleuroparenchymal fibroelastosis, IM immunosuppressant
  3. aExtensive PPFE vs. others (limited PPFE + no PPFE)
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Respiratory Research

ISSN: 1465-993X

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