Table 3 Demographic and clinical characteristics of subjects at baseline

Patients(n)

15

19

42

55

Age, years

62.53 ± 7.29

64.05 ± 10.99

63.55 ± 8.29

65.27 ± 06.28

Male, n (%)

13 (80)

17 94.7)

40 (95.2)

53 (96.4)

Current/Ever smoker, n

–

13/6

25/17

22 (33)

Smoking history (pack-years)^¥

–

35 (15)

40 (22)

40 (30)

BMI (kg/m²)

24.21 ± 2.70

23.27 ± 2.92

22.34 ± 3.20

22.09 ± 3.94^*

FEV₁(L)

2.26 ± 0.47

2.50 ± 0.45

1.70 ± 1.48^*△

0.80 ± 0.28^*△#

FEV₁% pred

101.13 ± 11.54

100.18 ± 16.60

54.29 ± 22.93^*△

31.54 ± 14.12^*△#

FVC(L)

2.97 ± 0.64

3.15 ± 0.63

2.96 ± 0.89

1.78 ± 0.51^*△#

FEV₁/FVC (%)

76.34 ± 5.11

79.67 ± 6.08

48.42 ± 12.53^*△

45.07 ± 10.44^*△

IC (L)

2.03 ± 0.45

2.11 ± 0.52

2.19 ± 0.67

1.22 ± 0.39^*△#

IC% pred

107.94 ± 17.13

102.23 ± 28.60

86.56 ± 27.23^*△

44.23 ± 27.00^*△#

Hb (g/L)

137.67 ± 15.12

134.63 ± 11.94

151.60 ± 13.44^△

133.65 ± 24.50^#

PLT (× 10⁹/L)

194.47 ± 46.24

199.26 ± 59.40

174.55 ± 58.44

186.20 ± 66.02

WBC (× 10⁹/L)

5.42 ± 0.91

5.29 ± 1.58

5.99 ± 1.50

8.12 ± 3.58^*△#

 Neu (× 10⁹/L)

3.28 ± 0.88

3.26 ± 1.15

3.64 ± 1.20

6.41 ± 3.57^*△#

 Lym (× 10⁹/L)

1.70 ± 0.45

1.42 ± 0.61

1.68 ± 0.52

1.11 ± 0.60^*△#

MONO (× 10⁹/L)

0.31 ± 0.09

0.37 ± 0.20

0.43 ± 0.15

0.50 ± 0.30^*△

EO (× 10⁹/L)

0.11 ± 0.05

0.12 ± 0.10

0.19 ± 0.14

0.13 ± 0.20

 Neu%

60.05 ± 8.79

61.33 ± 9.55

50.15 ± 7.79

74.96 ± 13.48^*△#

 Lym%

31.84 ± 8.29

26.74 ± 10.08

28.73 ± 7.33

16.17 ± 9.71^*△#

  MONO%

5.63 ± 1.36

6.78 ± 2.18

7.46 ± 1.63^*

6.49 ± 2.30^#

  EO%

2.05 ± 1.02

2.05 ± 1.22

3.27 ± 2.37^#

1.98 ± 3.10^#

  Neu/Lym

2.08 ± 0.83

3.66 ± 5.29

2.36 ± 1.24

9.49 ± 13.12^*△#

  EO/Lym

0.07 ± 0.04

0.10 ± 0.08

0.11 ± 0.08

0.10 ± 0.17