Table 3 Association between degree of lung function impairment and all-cause mortality restricted to people without previous history of COPD and never smokers
From: Impaired lung function and mortality in Eastern Europe: results from multi-centre cohort study
Type of groups | No. of persons | No. of deaths | Person-years of follow-up | Deaths per 100 person-years (95% CI) | Model 1 adjusted HR† (95% CI) | Model 2 Adjusted HR‡ (95% CI) |
|---|---|---|---|---|---|---|
No previous history of COPD and pulmonary symptoms | ||||||
FEV1% predicted impairment groups* | ||||||
Normal | 14,436 | 2413 | 190,254 | 1.27 (1.22–1.32) | 1.00 | 1.00 |
Mild | 1427 | 374 | 18,736 | 2.00 (1.80–2.21) | 1.51 (1.35–1.68) | 1.20 (1.07–1.35) |
Moderate | 516 | 175 | 6463 | 2.71 (2.33–3.14) | 1.88 (1.60–2.21) | 1.41 (1.20–1.66) |
Moderate-severe | 196 | 76 | 2337 | 3.25 (2.60–4.07) | 2.12 (1.64–2.73) | 1.59 (1.26–2.02) |
Severe | 117 | 38 | 1463 | 2.60 (1.89–3.57) | 1.83 (1.30–2.57) | 1.30 (0.93–1.82) |
Very severe | 31 | 12 | 360 | 3.34 (1.89–5.87) | 3.07 (1.68–5.61) | 2.13 (1.21–3.77) |
Never smokers | ||||||
FEV1% predicted impairment groups* | ||||||
Normal | 11,233 | 1537 | 147,841 | 1.04 (0.99–1.09) | 1.00 | 1.00 |
Mild | 1077 | 246 | 14,057 | 1.75 (1.54–1.98) | 1.56 (1.37–1.79) | 1.40 (1.21–1.62) |
Moderate | 407 | 111 | 5179 | 2.14 (1.78–2.58) | 1.89 (1.55–2.30) | 1.61 (1.32–1.98) |
Moderate-severe | 176 | 59 | 2096 | 2.81 (2.18–3.63) | 2.50 (1.89–3.31) | 2.17 (1.66–2.83) |
Severe | 104 | 33 | 1294 | 2.55 (1.81–3.59) | 2.39 (1.65–3.45) | 2.14 (1.50–3.07) |
Very severe | 36 | 19 | 397 | 4.79 (3.06–7.51) | 4.06 (2.43–6.80) | 4.03 (2.55–6.35) |