Fig. 6

CSE treatment stimulates proliferation of human PAECs, and celecoxib, beraprost sodium, and daltroban potently inhibit the proliferation. (A) confluent human PAECs were treated with or without CSE for up to 24 h, and then WST-1 assay was conducted. (B–D) confluent human PAECs were pre-treated with or without different concentrations of celecoxib (B), beraprost sodium (C), and daltroban (D) for 1 h before being treated with CSE for 24 h. WST-1 was then conducted. Data are expressed as relative proliferation (% change over control). Each data point represents mean ± SEM from three independent experiments using PAECs from one donor **P < 0.01, ****P < 0.0001 compared with control; ⁺P < 0.05, ⁺⁺P < 0.01, ⁺⁺⁺P < 0.001, ⁺⁺⁺⁺P < 0.0001 compared with CSE alone