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Table 2 Test characteristics of cases identified by the random forest algorithm when deployed on the Synthetic Derivative (including cases from the test set)

From: An algorithm to identify cases of pulmonary arterial hypertension from the electronic medical record

Test Characteristics

RF Algorithm in SD

RF Algorithm SD Non-Cases

French Registry

REVEAL

UK-Ireland Registry

n

265

2,270,971

674

2525

482

Age (years)

52.0 (13.7)

52.0 (21.4)

50.0 (15.0)

50.1 (14.4)

50.1 (17.1)

Sex, % female (n)

72.1% (191)

54.2% (1,253,660)

65.3%

79.5%

69.9%

Comorbidities

     

CTD (n)

33.2% (88)

2.0% (465)

15.3%

25%

CHD (n)

19.2% (51)

0.9% (19,950)

11.3%

10%

Medications

     

ERA (n)

70.6% (187)

 < 0.1% (26)

47%

44.2%

GS stimulators (n)

1.5% (4)

 < 0.1% (9)

PDE5 inhibitors (n)

84.2% (223)

0.4% (9,224)

49%

29.2%

Prostanoids (n)

63.0% (167)

 < 0.1% (2)

18.8%

Hemodynamics (n = 189)

 

(n = 8806)

   

RA pressure (mmHg)

10.1 (6.0)

8.8 (8.3)

8 (5.)

9.3 (5.6)

10.1 (6.0)

Mean PA (mmHg)

49.8 (13.6)

27.7 (11.7)

55 (15)

50.7 (13.6)

54.1 (13.9)

PWP (mmHg)

11.3 (6.1)

15.5 (8.3)

8.0 (3)

9.1 (3.5)

9.2 (3.5)

CO, Fick (L/min)

4.8 (2)

5.6 (3.7)

4.0 (1.5)**

CO, TD (L/min)

4.8 (1.7)

5.1 (2.4)

4.0 (1.5)**

CI, Fick (L/min/M2)

2.5 (1.0)

2.9 (2.7)

2.9 (0.9)*

2.4 (0.8)*

2.1 (6.3)

CI, TD (L/min/M2)

2.5 (0.8)

2.6 (2.2)

2.9 (0.9)*

2.4 (0.8)*

2.1 (6.3)

PVR (Wood units)

9.9 (5.9)

2.6 (2.5)

***

***

12.8 (6.3)

  1. SD  synthetic derivative, CTD  connective tissue disease, CHD  congenital heart disease, ERA  endothelin receptor antagonists, GC  guanylate cyclase, PDE5  phosphodiesterase type 5, RA  right atrial, PA  pulmonary arterial, PWP  pulmonary wedge pressure, CO  cardiac output, TD  thermodilution, CI  cardiac index, PVR  pulmonary vascular resistance. Data expressed as % (n) or mean (SD) unless otherwise noted. For French Registry [32], all values taken from Table 1. For REVEAL [34], demographics and hemodynamics are taken from Table 1, and medications are taken from Table 2. For UK-Ireland Registry [33], demographics and hemodynamics are taken from Table 1, and medications are taken from Table 2 (values added across all years, n = 479)
  2. *For REVEAL, Fick CI was used unless it was missing, in which case thermodilution CI was used. For French Registry, CI method was not indicated
  3. **Method not indicated
  4. ***PVRI was reported for French Registry (M = 20.5, SD = 10.2) and REVEAL (M = 21.1, SD = 12.5)