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Table 3 Functional annotation for top interaction networks

From: Th1 cytokines synergize to change gene expression and promote corticosteroid insensitivity in pediatric airway smooth muscle

Module

Co-expression Network Hub Gene

Number of Interactions

Number of Annotation Clusters

Top Functional Annotation Clusters within Co-expression Network

M1

CIT, Citron Rho-Interacting Serine/Threonine Kinase

1350

54

rRNA Processing, mRNA splicing, RNA binding, ATP binding, viral nucleoprotein

LGALS9, Galectin

444

43

viral transcription, Cell–cell adhesion, nucleotide binding, protein folding, endoplasmic reticulum, mitochondrion, ER-Golgi transport

VCAM1, Vascular Cell Adhesion Molecule 1

412

29

cell–cell adhesion, RNA-binding, protein folding, actin binding

ISG15, ISG15 Ubiquitin-like Modifier

164

19

cadherin binding, ATP-binding, glycolytic process, actin binding, MHC class II protein complex binding

SOCS1, Suppressor of Cytokine Signaling 1

86

24

ATP binding, MAPK cascade, tyrosine-protein kinase, JAK/Stat signaling pathway

M4

HCK, HCK Proto-Oncogene, Src Family Tyrosine Kinase

67

14

ATP binding, PI3K-Akt signaling, unfolded protein response, protein tyrosine kinase activity

TNFAIP3, TNF Alpha Induced Protein 3

50

17

NFκB signaling, toll like receptor signaling, ubiquitin-protein transferase activity, CD40 receptor complex, TNF signaling

BDKRB1, Bradykinin Receptor 1

30

2

Membrane, endoplasmic reticulum

MYH11, Myosin Heavy Chain 11

19

5

cytoskeleton, motor protein, myosin, cell division

CCL5, C–C Motif Chemokine Ligand 5

15

3

chemokine activity, leukocyte chemotaxis